7-Day Missouri Itinerary

A mix of big-city attractions, historic sites, scenic drives, and outdoor adventures across Missouri.

Day1

Arrive in St. Louis & Explore

Fly into St. Louis Lambert International Airport (STL).

Top Things to Do in St. Louis

  • Visit the Gateway ArchRide to the top for amazing views.
  • Eat on the McDonald's RiverboatA nostalgic dining experience on the Mississippi River.
  • Catch a St. Louis Cardinals Game at Busch Stadium (Seasonal).
  • Tour the Anheuser-Busch BreweryHome of Budweiser.
  • Dinner at Pappy's SmokehouseFamous for St. Louis-style ribs.

Overnight in St. Louis.

Day2

St. Louis History & Lewis & Clark Expedition

Explore More of St. Louis.

Top Things to Do

  • Visit the Missouri History MuseumLearn about the Lewis & Clark Expedition.
  • Explore Forest ParkHome to the St. Louis Zoo (one of the best free zoos in the country!).
  • Check Out City MuseumA giant playground for kids and adults alike.
  • Take a Riverboat Cruise on the Mississippi.

Overnight in St. Louis.

Day3

Route 66 & Meramec Caverns

Drive from St. Louis to Meramec Caverns (1.5 hours).

Top Things to Do

  • Tour Meramec CavernsA famous cave system tied to Jesse James.
  • Drive a Stretch of Historic Route 66Stop at quirky roadside attractions.
  • Lunch at The FourWayA classic Route 66 diner.

Drive to Springfield, MO (2 hours).

Overnight in Springfield.

Day4

Springfield & Wilson's Creek National Battlefield

Explore Springfield, Missouri.

Top Things to Do

  • Visit Wilson's Creek National BattlefieldA key Civil War site.
  • Check Out the Wonders of Wildlife National Museum & Aquarium.
  • Stop by the Original Bass Pro ShopsThe Largest in the World!
  • Dinner at Lambert's CafeHome of the "throwed rolls."

Overnight in Springfield.

Day5

Branson - Live Entertainment & Outdoor Fun

Drive from Springfield to Branson (1 hour).

Top Things to Do in Branson

  • See a Live Music ShowThe "Live Entertainment Capital of the World!"
  • Explore Silver Dollar CityA Wild West-style theme park.
  • Take a Boat Ride on Table Rock Lake.
  • Dinner at Dolly Parton's StampedeA fun dinner show experience.

Overnight in Branson.

Day6

Lake of the Ozarks - Boating & Caves

Drive from Branson to Lake of the Ozarks (2.5 hours).

Top Things to Do at Lake of the Ozarks

  • Rent a Boat or Go Fishing on the Lake.
  • Hike in Ha Ha Tonka State ParkSee castle ruins with a view!
  • Explore Bridal CaveA Stunning Underground Lake Cave.
  • Dinner at Baxter's Lakeside Grille.

Overnight at Lake of the Ozarks.

Day7

Return to St. Louis & Depart

Drive from Lake of the Ozarks to St. Louis (3 hours).

Optional Stops Along the Way

  • Visit Hermann, MOMissouri's wine country for a tasting.
  • Stop at Daniel Boone Home in Defiance, MO.

Fly out of St. Louis (STL).

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Header photo: Daniel Schwen, CC BY-SA 4.0, via Wikimedia Commons.