7-Day Mississippi Itinerary

A mix of Southern history, Delta blues, riverfront towns, and Gulf Coast charm across Mississippi.

Day1

Arrive in Jackson & Explore

Fly into Jackson-Medgar Wiley Evers International Airport (JAN).

Top Things to Do in Jackson

  • Visit the Mississippi Civil Rights MuseumA powerful and moving experience.
  • Explore the Mississippi Museum of Art.
  • Tour the Eudora Welty House & GardenHome of the famous author.
  • Dinner at the Mayflower CafeA classic spot for Southern cuisine.

Overnight in Jackson.

Day2

Natchez - Historic Riverfront & Antebellum Homes

Drive from Jackson to Natchez (1.5 hours).

Top Things to Do in Natchez

  • Tour Longwood or Stanton HallStunning antebellum mansions.
  • Walk the Natchez Bluff TrailBeautiful views over the Mississippi River.
  • Drive the Natchez Trace ParkwayA historic and scenic route.
  • Dinner & Sunset Drinks at Magnolia Grill.

Overnight in Natchez.

Day3

Vicksburg - Civil War History & River Views

Drive from Natchez to Vicksburg (1.5 hours).

Top Things to Do in Vicksburg

  • Visit the Vicksburg National Military ParkA key Civil War battlefield.
  • Tour the Old Courthouse MuseumFull of Civil War artifacts.
  • Try Your Luck at Riverfront Casinos.
  • Eat at The BeechwoodA legendary local steakhouse.

Overnight in Vicksburg.

Day4

The Mississippi Delta - Blues & Culture

Drive from Vicksburg to Clarksdale (2 hours).

Top Things to Do in Clarksdale

  • Visit the Delta Blues Museum.
  • See the "Crossroads" Where Robert Johnson Allegedly Sold His Soul.
  • Lunch at Abe's BBQA Delta favorite since 1924.
  • Catch Live Blues at Red's Lounge or Ground Zero Blues Club.

Overnight in Clarksdale.

Day5

Oxford - College Town & Literary History

Drive from Clarksdale to Oxford (1.5 hours).

Top Things to Do in Oxford

  • Visit Rowan OakHome of William Faulkner.
  • Explore the Historic Oxford Square.
  • Enjoy Dinner at City Grocery.

Overnight in Oxford.

Day6

Mississippi Gulf Coast - Biloxi & Ocean Springs

Drive from Oxford to Biloxi (5 hours).

Top Things to Do in Biloxi & Ocean Springs

  • Relax on the White Sand Beaches.
  • Visit a Biloxi Casino Like Beau Rivage.
  • Tour the Ohr-O'Keefe Museum of Art.
  • Dinner at The Blind Tiger or Half Shell Oyster House.

Overnight in Biloxi or Ocean Springs.

Day7

Gulf Islands National Seashore & Depart

Explore the Gulf Coast Before Heading Back.

Top Things to Do

  • Take a Ferry to Ship Island.
  • Explore Davis Bayou in Gulf Islands National Seashore.

Fly out of Gulfport-Biloxi International Airport (GPT) or drive back to Jackson (3.5 hours).

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Header photo: P. Hughes, CC BY-SA 4.0, via Wikimedia Commons.